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The following settings are available on the tab:

Path to downloaded Downloaded data — specifies the path where files downloaded from the remote databases will be stored.

Path for temporary Documents - the path where will be stored UGENE data.

Temporary files — the path where will be stored temporary files.

File storage — the path where will be stored UGENE files. 

Build indexes - the path where will be stored UGENE Genome Aligner indexes.