UGENE takes care to use capabilities of your system: the more RAM and cores you have, the more quickly you'll get results of your calculations.
Also, if you have an OpenCL-capable video card, you can use GPU-optimized versions of the following tools:
In most cases it is recommended to use UGENE full package, as it embeds additional external tools, such as local BLAST, Bowtie, etc. When the full package is used, the external tools can be run out of the box.
The list of the external tools and their availability for different operating systems can be seen on this page.
For details about UGENE packages, see this page.