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By holding the Shift key it is possible to select a region between two coordinates of a mouse click. For example, if there is a big alignment, one can click on a character (the left upper coordinate of the region), press Shift, scroll to the required location of the alignment, and click on another character (the right bottom coordinate of the region).
It is possible to modify a selection in the Sequence Area by dragging the border of its selection rectangle border:
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