The lock icon in the document element indicates that the document can’t be modified:
<center> <br> <img src="/wiki/download/attachments/17467504/Locked Documents.png"/> <br> </center>
UGENE does not allow modification of some formats that were created not by UGENE.
If UGENE is able only to read a document (see the Supported File Formats chapter), you can export the document objects to a file. To do it use the built-in export utilities.
Also, you can export the document objects of unlocked documents.