The lock icon in the document element indicates that the document can’t be modified:

     <img src="/wiki/download/attachments/17467504/Locked Documents.png"/>

UGENE does not allow modification of some formats that were created not by UGENE.

If UGENE is able only to read a document (see the Supported File Formats chapter), you can export the document objects to a file. To do it use the built-in export utilities.

Also, you can export the document objects of unlocked documents.