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When open UGENE for the first time, there is an empty UGENE window with the main menu bar on the top of the window: 

HTML
<center>
  <br>
  <img src="/wiki/download/attachments/2523429/ugene_main_window.gif"/>
  <br>
</center>

Using these menus you can run many algorithms, configure different settings and get help: 

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