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The tool was added in version 50.

The 'mfold' software is a tool for nucleic acid folding and hybridization prediction. It was developed by M. Zuker in the late 1980s for RNA folding and improved for DNA folding in 1996. mfold uses nearest neighbor energy rules.

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This is what the mfold dialog looks likelike on Windows OS

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screenshot
screenshot

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Some dialog fields retain their state between dialog calls. For such fields, the ability to reset settings is also available (the "Reset settings" button at the bottom left in the screenshot of the dialog). Below is a table showing which states are saved between dialog calls and which of them can be reset to default values.


Save statesReset states
Algorithm settingsyes (it can be tedious to enter fields every time)yes
Display settings
Regionno (since the region is optionally selected manually by the user)no (the same reason)
Output settingsyesno (these unique settings are changed manually by the user when the user really needs it; a quick reset only makes sense for algorithmic settings)
Info

States are saved only for a specific sequence window. Thus, if you have two windows (or two views) for sequence-1 and one window for sequence-2, then each window will have its own state for the mfold dialog.

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